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Pbx 1b Antibody (41.1) is an IgG1 κ mouse monoclonal Pbx 1b antibody (also designated PBX Homeobox 1 antibody, Pre-B-Cell Leukemia Transcription Factor 1 antibody, Pre-B-Cell Leukemia Homeobox 1 antibody, Homeobox Protein PBX1 antibody, Homeobox Protein PRL antibody, or PRL antibody) suitable for the detection of the Pbx 1b protein of mouse, rat and human origin by WB, IP, IF and IHC(P). Pbx 1b Antibody (41.1) is available as both the non-conjugated anti-Pbx 1b antibody form, as well as multiple conjugated forms of anti-Pbx 1b antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Pbx 1, 2, 3 and 4 are members of the TALE (three amino acid loop extension) family of homeodomain-containing proteins. Human pre-B cell acute leukemias are frequently associated with a t(1;19)(q23;p13.3) chromosomal rearrangement, which creates a chimeric gene encoding a fusion between the E2A and Pbx 1 gene products. Pbx 2 and Pbx 3 share 92% and 94% respective identities with Pbx 1 over a 266 amino acid region flanking their homeobox domains, while all three proteins are quite divergent at their amino- and carboxy-termini. Two forms of Pbx 1 and Pbx 3 each differ primarily in their carboxy-termini and result from alternative mRNA splicing. Unlike other homeotic selector genes which are expressed transiently during development and differentiation, Pbx gene transcripts are ubiquitously expressed in both fetal and adult tissues and cell lines. Additionally, Pbx 2 and Pbx 3 transcripts are detected in lymphoid cells, which do not express Pbx 1. Pbx 4 expression is confined to the testis, especially to spermatocytes in the pachytene stage of the first meiotic prophase.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Rated 1 out of
no signal in IF in brainI didn't detect staining signal in 4% PFA fixed embryonic mouse brain sections.
Date published: 2018-01-18
Rated 5 out of
High Quality AntibodyThe Pbx 1b Antibody (41.1): sc-101852 provides excellent data for IHC with formalin fixed, paraffin-embedded tissue sections. This antibody has also been cited several times for further verification.
Date published: 2017-02-03
Rated 4 out of
Produced great immunoperoxidase nuclear stainingProduced great immunoperoxidase nuclear staining in formalin fixed, paraffin-embedded human ovary tissue. -SCBT QC
Date published: 2015-04-12
Rated 4 out of
IF publishable data with human MCF7 cell lineIF publishable data with human MCF7 cell line - SCBT Publication Review