Pbx 1a/2/3a 抗体 (359.15): sc-101856

Pbx 1a/2/3a Antibody (359.15) is an IgG₁ κ mouse monoclonal Pbx 1a/2/3a antibody (also designated pan-PBX Homeobox antibody, pan-PBX antibody, PBX1 antibody, PBX2 antibody, PBX3 antibody, PBX Homeobox antibody, Pre-B-Cell Leukemia Transcription Factor antibody, Pre-B-Cell Leukemia Homeobox antibody, or Homeobox Protein antibody) that detects the Pbx 1a/2/3a protein of mouse, rat and human origin by WB, IP, IF and IHC(P). Pbx 1a/2/3a Antibody (359.15) is available as the non-conjugated anti-Pbx 1a/2/3a antibody. Pbx 1, 2, 3 and 4 are members of the TALE (three amino acid loop extension) family of homeodomain-containing proteins. Human pre-B cell acute leukemias are frequently associated with a t(1;19)(q23;p13.3) chromosomal rearrangement, which creates a chimeric gene encoding a fusion between the E2A and Pbx 1 gene products. Pbx 2 and Pbx 3 share 92% and 94% respective identities with Pbx 1 over a 266 amino acid region flanking their homeobox domains, while all three proteins are quite divergent at their amino- and carboxy-termini. Two forms of Pbx 1 and Pbx 3 each differ primarily in their carboxy-termini and result from alternative mRNA splicing. Unlike other homeotic selector genes which are expressed transiently during development and differentiation, Pbx gene transcripts are ubiquitously expressed in both fetal and adult tissues and cell lines. Additionally, Pbx 2 and Pbx 3 transcripts are detected in lymphoid cells, which do not express Pbx 1. Pbx 4 expression is confined to the testis, especially to spermatocytes in the pachytene stage of the first meiotic prophase.