p150 抗体 (JK-13): sc-100798

p150 Antibody (JK-13) is an IgG_2a κ mouse monoclonal p150 antibody (also designated p150 antibody) that detects the p150 protein of human origin by WB, IP and ELISA. p150 Antibody (JK-13) is available as the non-conjugated anti-p150 antibody. Accurate sorting and delivery of proteins to the proper organelles is essential for normal cellular functioning. The yeast Vps proteins are involved in sorting and delivering vacuolar proteins from the Golgi network, where they undergo posttranslational modification, to the vacuole. Vps34p, a key component of this protein trafficking system, shares homology with proteins in the PI 3-kinase family and is regulated by Vps15p. Vps15p is thought to recruit Vps34p to the membrane of the Gogli complex and to enhance Vps34p kinase activity. p150 is the human homolog of the yeast Vps15p and is ubiquitously expressed. p150, like Vps15p, is subject to posttranslational modification, including myristalation.

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References:

1. Protein targeting to the yeast vacuole.  |  Rothman, JH., et al. 1989. Trends Biochem Sci. 14: 347-50. PMID: 2529676
2. A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system.  |  Volinia, S., et al. 1995. EMBO J. 14: 3339-48. PMID: 7628435
3. Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast.  |  Stack, JH., et al. 1995. J Cell Biol. 129: 321-34. PMID: 7721937
4. Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities.  |  Stack, JH. and Emr, SD. 1994. J Biol Chem. 269: 31552-62. PMID: 7989323
5. Receptor-mediated protein sorting to the vacuole in yeast: roles for a protein kinase, a lipid kinase and GTP-binding proteins.  |  Stack, JH., et al. 1995. Annu Rev Cell Dev Biol. 11: 1-33. PMID: 8689553
6. Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex.  |  Panaretou, C., et al. 1997. J Biol Chem. 272: 2477-85. PMID: 8999962