Nup98 抗体 (2H10): sc-101546

Nuclear pore complexes (NPCs) are the channels for the bi-directional movement of macromolecules between the nucleus and cytoplasm, and contain more than 100 different subunits. Many of them belong to a family called nucleoporins, which are characterized by the presence of O-linked N-acetylglucosamine moieties and a distinctive pentapeptide repeat (XFXFG). The NUP98 gene encodes precursor proteins that generate two nucleoplasmically oriented nucleoporins, Nup98 and Nup96. The O-linked glycoprotein, Nup98 is a component of the nuclear pore complex. Nup98 is essential for gastrulation, a developmental stage that is associated with rapid cell proliferation, but dispensable for basal cell growth. Nup98 plays a role in RNA export from the nucleus and it appears to be an essential component of multiple RNA export pathways. Nup98 is a member of the GLFG nucleoporin family. The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for Nup98 and class I homeoprotein HoxA9. Nup98-HoxA9 fusion protein may promote leukemogenesis through inhibiting of HoxA9-mediated terminal differentiation and/or aberrant nucleocytoplasmic transport.