NUDT10 抗体 (4B7): sc-100571

NUDT10 (nudix (nucleoside diphosphate linked moiety X)-type motif 10), also known as APS2 (Ap6A hydrolase 2) or DIPP3α (diphosphoinositol polyphosphate phosphohydrolase 3 α), is a member of the Nudix hydrolase family of pyrophosphatases. Nudix hydrolases contain a characteristic Nudix domain and are responsible for catalyzing the hydrolysis of nucleoside diphosphate derivatives. NUDT10 functions as a manganese-dependent polyphosphate phosphohydrolase with an optimum pH of 8.5. NUDT10 specifically metabolizes diadendosine-polyphosphates and, to a lesser extent, diphosphoinositol polyphosphates. Localizing to the cytoplasm, NUDT10 is predominantly expressed in brain and liver tissues, but is also found in prostate, testis, ovary, kidney, pancreas, placenta, spleen, lung and heart. NUDT10 is very closely related to NUDT11; the two proteins differ from one another by only one amino acid.