NRBP 抗体 (X-13): sc-101288

The nuclear receptor binding protein (NRBP) is a host cellular protein that influences the subcellular trafficking between the endoplasmic reticulum (ER) and the Golgi apparatus via interactions with GTPases. As a multidomain putative adaptor protein, NRBP modulates multiple signaling pathways by regulating the formation of signaling complexes in the cytoplasm. NRBP, which can form a homodimer, binds to MLF1. This binding recruits a serine kinase which phosphorylates both of the proteins, preventing MLF1 from binding to YWHAZ. It is a cytoplasmic protein, but it can co-localize with RAC3 to the endomembrane and can be seen at the cell periphery in lamellipodia. The NRBP gene maps to human chromosome 2p23 and is ubiquitously expressed in human tissues, with highest levels detected in testis.