Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
NPR-B Antibody (1E4) is a high quality monoclonal NPR-B antibody (also designated NPR2 antibody, Guanylate cyclase B (GC-B) antibody or ANPRB antibody) suitable for the detection of the NPR-B protein of mouse, rat and human origin. NPR-B Antibody (1E4) is available as the non-conjugated anti-NPR-B antibody. The natriuretic peptides are a group of structurally similar peptides that are genetically distinct and play a role in several processes, including cardiovascular, renal and endocrine homeostasis. The atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are derived from myocardial cell origin and are cardiac hormones secreted from the atrium and ventricle of the heart, respectively. The C-type natriuretic peptide (CNP) is derived from endothelial cell origin and acts as an endothelium-derived relaxing factor (EDRF). These peptides mediate their effects through three receptors. NPR-A (also designated GC-A) binds both ANP and BNP, which stimulates 3′, 5′-cyclic guanosine monophosphate (cGMP) to mediate natriuresis, vasodilation, renin inhibition, antimitogenesis and lusitropic properties. NPR-B (also designated GC-B) binds CNP and also stimulates cGMP to facilitate vasodilation and growth inhibition. NPR-C, also designated the ′clearance′ receptor, clears all three peptides, which are subsequently degraded by the ectoenzyme neutral endopeptidase. The natriuretic peptide system plays an important role in hypertension, congestive heart failure, atherosclerosis and renal diseases, and may be a therapeutic target in the treatment of these diseases.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.