Neu/ErbB2/HER2 抗体 (9G6): sc-08

Neu/ErbB2/HER2 Antibody (9G6) is an IgG1 mouse monoclonal Neu antibody suitable for the detection of Neu gp185 of human origin. Neu/ErbB2/HER2 Antibody (9G6) is available as the non-conjugated anti-Neu antibody form. The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3), and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Neu, a glycoprotein, undergoes transactivation upon hetero-dimerization with other EGF receptor family members. Neu heterodimerization with ErbB-3 recruits heregulin, which induces phosphoinositide (PI) 3-kinase activation. Activation of Neu potentiates tumor cell motility and protease secretion and invasion, and also modulates cell cycle checkpoint function, DNA repair and apoptotic responses. Amplification and/or overexpression of Neu occurs in 20-30% of breast carcinomas. Measurement of increased Neu expression can be a predictor of disease prognosis. Neu may also prove to be a promising target for therapeutic agents.

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References:

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2. Heregulin-dependent activation of phosphoinositide 3-kinase and Akt via the ErbB2/ErbB3 co-receptor.  |  Hellyer, NJ., et al. 2001. J Biol Chem. 276: 42153-61. PMID: 11546794
3. HER-2/neu-derived peptide epitopes are also recognized by cytotoxic CD3(+)CD56(+) (natural killer T) lymphocytes.  |  Baxevanis, CN., et al. 2002. Int J Cancer. 98: 864-72. PMID: 11948464
4. The role of c-erbB-2/HER2/neu in breast cancer progression and metastasis.  |  Eccles, SA. 2001. J Mammary Gland Biol Neoplasia. 6: 393-406. PMID: 12013529
5. Gene amplification and mRNA and protein overexpression of c-erbB-2 (HER-2/neu) in human intrahepatic cholangiocarcinoma as detected by fluorescence in situ hybridization, in situ hybridization, and immunohistochemistry.  |  Ukita, Y., et al. 2002. J Hepatol. 36: 780-5. PMID: 12044528
6. c-erbB-2 in breast cancer: development of a clinically useful marker.  |  Hayes, DF. and Thor, AD. 2002. Semin Oncol. 29: 231-45. PMID: 12063676
7. Colonic epithelial expression of ErbB2 is required for postnatal maintenance of the enteric nervous system.  |  Crone, SA., et al. 2003. Neuron. 37: 29-40. PMID: 12526770
8. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab.  |  Cho, HS., et al. 2003. Nature. 421: 756-60. PMID: 12610629
9. Synapses form in skeletal muscles lacking neuregulin receptors.  |  Escher, P., et al. 2005. Science. 308: 1920-3. PMID: 15976301