netrin G2 抗体 (Y-18L): sc-100330

netrin G2 Antibody (Y-18L) is an IgG_2b κ mouse monoclonal netrin G2 antibody (also designated Laminet-2 antibody or NTNG2 antibody) suitable for the detection of the netrin G2 protein of mouse, rat and human origin by WB, IP and ELISA. netrin G2 Antibody (Y-18L) is available as the non-conjugated anti-netrin G2 antibody. Netrin G1 and Netrin G2, also referred to as laminet-1 and laminet-2, are membrane bound axon guidance molecules involved in synaptic formation and maintenance. They comprise a subgroup within the UNC-6/netrin family. Both genes have been associated with schizophrenia involving single nucleotide polymorphisms. They are both expressed in the brain but G1 is most predominantly expressed in the thalamus and G2 is most predominantly expressed in the cortex and hippocampus. These two proteins differ from classical netrins by their failure to bind netrin receptors, the presence of a glycosyl phosphatidylinositol membrane anchor, and the generation of multiple isoforms. Netrin G2 contains one laminin N-terminal domain and three laminin EGF-like domains. It selectively interacts with LRRC4 and this association may mediate cell adhesion. In addition, Netrin G2 is significantly downregulated in bladder transitional cell carcinoma (TCC) and may be a putative tumor suppressor gene.

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References:

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2. Expression in bladder transitional cell carcinoma by real-time quantitative reverse transcription polymerase chain reaction array of 65 genes at the tumor suppressor locus 9q34.1-2: identification of 5 candidates tumor suppressor genes.  |  Amira, N., et al. 2004. Int J Cancer. 111: 539-42. PMID: 15239131
3. A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia.  |  Aoki-Suzuki, M., et al. 2005. Biol Psychiatry. 57: 382-93. PMID: 15705354
4. Human netrin-G1 isoforms show evidence of differential expression.  |  Meerabux, JM., et al. 2005. Genomics. 86: 112-6. PMID: 15901489
5. Strong expression of NETRIN-G2 in the monkey claustrum.  |  Miyashita, T., et al. 2005. Neuroscience. 136: 487-96. PMID: 16203099
6. NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formation.  |  Kim, S., et al. 2006. Nat Neurosci. 9: 1294-301. PMID: 16980967
7. Hooking up new synapses.  |  Biederer, T. 2006. Nat Neurosci. 9: 1203-4. PMID: 17001334
8. Decreased mRNA expression of netrin-G1 and netrin-G2 in the temporal lobe in schizophrenia and bipolar disorder.  |  Eastwood, SL. and Harrison, PJ. 2008. Neuropsychopharmacology. 33: 933-45. PMID: 17507910
9. Axonal netrin-Gs transneuronally determine lamina-specific subdendritic segments.  |  Nishimura-Akiyoshi, S., et al. 2007. Proc Natl Acad Sci U S A. 104: 14801-6. PMID: 17785411