myomegalin 抗体 (S-17): sc-100921

myomegalin Antibody (S-17) is a high quality monoclonal myomegalin antibody (also designated myomegalin antibody) suitable for the detection of the myomegalin protein of human origin. myomegalin Antibody (S-17) is available as the non-conjugated anti-myomegalin antibody. Myomegalin, also known as PDE4DIP (Phosphodiesterase 4D-interacting protein), CMYA2 (Cardiomyopathy-associated protein 2) or MMGL, is a 2,346 amino acid protein that contains one NBPF domain and localizes to the nucleus, cytoplasm, centrosome and Golgi apparatus. Expressed at high levels in fetal and adult heart and at lower levels in brain and placenta, myomegalin is thought to function as an anchoring protein that sequesters members of the cAMP-dependent pathway to the Golgi and to centrosomes, thereby mediating cAMP pathway dynamics. Translocations in the gene that encodes myomegalin are associated with myeloproliferative disorders (MBDs), a group of diseases caused by an overproduction of blood cells. Myomegalin exists as twelve isoforms due to alternative splicing events.