MYL6B 抗体 (YY-06): sc-100951

MYL6B Antibody (YY-06) is an IgG_2b κ mouse monoclonal MYL6B antibody (also designated MYL6B antibody) that detects the MYL6B protein of human origin by WB, IP and ELISA. MYL6B Antibody (YY-06) is available as the non-conjugated anti-MYL6B antibody. MYL6B (Myosin light chain 6B) is a heavy chain regulator found in smooth muscle and non-muscle Myosin complexes. Three general classes of Myosin have been cloned: smooth muscle myosins, striated muscle myosins and non-muscle myosins. Contractile activity in smooth muscle is regulated by the calcium/calmodulin-dependent phosphorylation of myosin light chain by myosin light chain kinase. Myosin heavy chains are encoded by the MYH gene family and have Actin-activated ATPase activity which generates the motor function of Myosin. Although it contains three of the EF-hand domains common to Actin and other Myosin regulating proteins, MYL6B does not bind calcium during contraction. It is primarily found in a hexamer consisting of four light chains and two heavy chains. It most commonly interacts with Myosin Va, an Actin based motor that can move in large steps. MYL6B is expressed in most tissues with neurons and smooth muscle tissue having the highest expression.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

References:

1. Expression of the alpha 6A integrin splice variant in developing mouse embryonic stem cell aggregates and correlation with cardiac muscle differentiation.  |  Thorsteinsdóttir, S., et al. 1999. Differentiation. 64: 173-84. PMID: 10234814
2. Purification and characterization of smooth muscle myosin-associated phosphatase from chicken gizzards.  |  Mitsui, T., et al. 1992. J Biol Chem. 267: 16727-35. PMID: 1322916
3. Increase of vinblastine accumulation by inhibitors of calmodulin-dependent cell functions in rat ascites hepatoma AH66 cells.  |  Wakusawa, S., et al. 1992. Anticancer Res. 12: 2021-4. PMID: 1363514
4. Myosin light chain isoform expression among single mammalian skeletal muscle fibers: species variations.  |  Bicer, S. and Reiser, PJ. 2004. J Muscle Res Cell Motil. 25: 623-33. PMID: 15750847
5. A highly sensitive technique to measure myosin regulatory light chain phosphorylation: the first quantification in renal arterioles.  |  Takeya, K., et al. 2008. Am J Physiol Renal Physiol. 294: F1487-92. PMID: 18400874
6. Purification and properties of troponin T kinase from rabbit skeletal muscle.  |  Kumon, A. and Villar-Palasi, C. 1979. Biochim Biophys Acta. 566: 305-20. PMID: 33714
7. Purification and characterization of rabbit liver calmodulin-dependent glycogen synthase kinase.  |  Payne, ME., et al. 1983. J Biol Chem. 258: 2376-82. PMID: 6296143
8. Partial purification and characterization of myosin light chain kinase from bovine thyroid gland.  |  Tawata, M., et al. 1983. Endocrinology. 112: 701-6. PMID: 6687357