MVD 抗体 (2B5): sc-100559

MVD (mevalonate (diphospho) decarboxylase), also known as MPD (mevalonate pyrophosphate decarboxylase), is a 400 amino acid protein that belongs to the diphosphomevalonate decarboxylase family. Expressed in lung, liver, heart, skeletal muscle, brain, pancreas, placenta and kidney, MVD enzymatically catalyzes the first step in isoprene biosynthesis, namely the ATP-dependent conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate, a cholesterol precursor. MVD exists as a homodimer that simultaneously dehydrates and decarboxylates its substrate while hydrolyzing ATP. As MVD is a crucial enzyme in early cholesterol synthesis, it may be a useful target for drugs that aim to lower serum cholesterol levels.