MTUS1 抗体 (31-Y): sc-100293

MTUS1 (mitochondrial tumor suppressor 1), also known as ATIP (angiotensin-II type 2 receptor (AT2)-interacting protein), MP44, GK1 or MTSG1, is a ubiquitously expressed protein with highest expression in brain tissues. MTUS1 is predominantly hydrophilic and contains a large coiled coil domain and two leucine zippers. It interacts with the C-terminal tail of AT2 and cooperates with this receptor to mediate the inhibition of growth factor-induced ERK 2 activation and cell proliferation. MTUS1 functions as a tumor suppressor and mutations in the gene encoding MTUS1 may result in hepatocellular carcinoma (HCC). Five transcript variants of MTUS1 are produced by alternative splicing events, namely ATIP1, ATIP2, ATIP3a, ATIP3b and ATIP4. ATIP1 exhibits cytosolic localization and ATIP4 localizes to the plasma membrane. ATIP2, ATIP3a and ATIP3b localize to the nucleus and are highly conserved throughout evolution, implying an important function for each in cellular homeostasis.