MTHFD2 抗体 (243.1): sc-100750

MTHFD2 (Methylenetetrahydrofolate dehydrogenase 2), also known as NMDMC, is a 350 amino acid bifunctional protein that is responsible for the consecutive interconversion of tetrahydrofolate derivatives which drive the synthesis of purine, methionine and thymidylate. MTHFD2 is bifunctional in that it has methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activity. MTHFD2 requires either NADP or NAD as a cofactor for interconversion. Activity of these cofactors is affected by intracellular magnesium and phosphate concentrations. MTHFD2 functions as a homodimer and is localized to the mitochondria where it is expressed during the development of normal tissue.