MTHFD1L 抗体 (6C7): sc-100783

Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) is a 935-amino acid, folate-dependent protein that is responsible for the consecutive interconversion of tetrahydrofolate derivatives which drive the synthesis of purine, methionine and thymidylate. MTHFD1 functions as a homodimer consisting of two major domains; an N-terminal domain containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain in the C-terminus. Mutations in the MTHFD1 gene in pregnant women are associated with an increased risk of giving birth to a child with a neural tube defect, along with a possible risk of decreased embryo survival. MTHFD1L (methylenetetrahydrofolate dehydrogenase 1-like) is a 978 amino acid mitochondrial protein that is expressed in a variety of tissues and, like MTHFD1, functions in folate metabolism via the tetrahydrofolate pathway. MTHFD1L exists as two isoforms and may be associated with colorectal carcinogenesis, possibly conferring a growth advantage to cancer-transformed cells.