MT-MMP-6 抗体 (MM0029-2B5): sc-101453

MT-MMP-6 Antibody (MM0029-2B5) is an IgG₁ mouse monoclonal MT-MMP-6 antibody (also designated MT-MMP-6 antibody) that detects the MT-MMP-6 protein of human origin by WB, IF and IHC(P). MT-MMP-6 Antibody (MM0029-2B5) is available as the non-conjugated anti-MT-MMP-6 antibody. The matrix metalloproteinases (MMPs) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, Fibronectin, Laminin and proteoglycan. MMP catalysis requires both calcium and zinc. Membrane-type matrix metalloproteinases are type I membrane proteins that function to activate other MMPs. MT-MMP activation appears to be mediated by members of the proprotein convertase family, suggesting that a proprotein convertase/MT-MMP/MMP cascade may be involved in the regulation of ECM turnover. MT-MMP-6 (also known as MMP-25, MT6-MMP or Leukolysin) is the second GPI-anchored proteinase in the MMP family. Similar to MMP-3, MT-MMP-6 is able to cleave type IV collagen, Fibronectin, fibrin and gelatin. However, MT-MMP-6 cannot cleave Laminin-1 or activate progelatinase B. MT-MMP 6 is expressed in leukocytes, lung and spleen.

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References:

1. Leukolysin/MMP25/MT6-MMP: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage.  |  Pei, D. 1999. Cell Res. 9: 291-303. PMID: 10628838
2. Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors.  |  Velasco, G., et al. 2000. Cancer Res. 60: 877-82. PMID: 10706098
3. Membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP-25) is the second glycosyl-phosphatidyl inositol (GPI)-anchored MMP.  |  Kojima, S., et al. 2000. FEBS Lett. 480: 142-6. PMID: 11034316
4. Catalytic activities of membrane-type 6 matrix metalloproteinase (MMP25).  |  English, WR., et al. 2001. FEBS Lett. 491: 137-42. PMID: 11226436
5. Direct activation of pro-matrix metalloproteinase-2 by leukolysin/membrane-type 6 matrix metalloproteinase/matrix metalloproteinase 25 at the asn(109)-Tyr bond.  |  Nie, J. and Pei, D. 2003. Cancer Res. 63: 6758-62. PMID: 14583471
6. MMP25 (MT6-MMP) is highly expressed in human colon cancer, promotes tumor growth, and exhibits unique biochemical properties.  |  Sun, Q., et al. 2007. J Biol Chem. 282: 21998-2010. PMID: 17513868
7. MT4-(MMP17) and MT6-MMP (MMP25), A unique set of membrane-anchored matrix metalloproteinases: properties and expression in cancer.  |  Sohail, A., et al. 2008. Cancer Metastasis Rev. 27: 289-302. PMID: 18286233