MSG1 抗体 (35-W): sc-101002

Pigmentation is a highly characteristic and distinguishing feature of differentiated melanocytes. Generally speaking, pigmentation decreases with melanoma progression and/or loss of several other differentiated properties of melanocytes. The gene which encodes the MSG1 protein is expressed at high levels in strongly pigmented melanoma cells, but at low levels in weakly pigmented cells, suggesting that MSG1 may be associated with pigmentation. MSG1, also designated CITED1, localizes to the nucleus and only demonstrates expression in melanocytes and testis. The deduced 193 amino acid human MSG1 protein shares 75% sequence homology with mouse MSG1. The MSG1 protein contains a serine/threonine-rich region, and research indicates that a fusion protein containing MSG1 and a DNA-binding domain activates transcription in mammalian cells, the activation of which is dependent upon the acidic domain of MSG1.