MMP-26 抗体 (TG-9): sc-100558

MMP-26 Antibody (TG-9) is an IgG_2a κ mouse monoclonal MMP-26 antibody (also designated MMP26 antibody) that detects the MMP-26 protein of human origin by WB, IP and ELISA. MMP-26 Antibody (TG-9) is available as the non-conjugated anti-MMP-26 antibody. Metalloproteinases (MMPs) are a family of proteins that are involved in the breakdown of the extracellular matrix during normal cellular events, including reproduction, tissue remodeling and embryonic development. MMP-26 (matrix metallopeptidase-26), also known as Endometase or Matrilysin-2, is a 261 amino acid metalloproteinase that is secreted as an inactive protein and is activated upon cleavage by extracellular proteinases. Expressed specifically in the placenta and uterus, MMP-26 hydrolyzes (and subsequently degrades) a variety of proteins such as Fibrinogen, Fibronectin, Vitronectin and collagen type IV (COL4). MMP-26 binds zinc and calcium as cofactors and, unlike other MMP family members, lacks a conserved C-terminal domain. MMP-26 is widely expressed in a number of malignant tumor lines where it is thought to play an important role in tissue remodeling events that are associated with carcinogenesis.

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References:

1. Identification and characterization of human endometase (Matrix metalloproteinase-26) from endometrial tumor.  |  Park, HI., et al. 2000. J Biol Chem. 275: 20540-4. PMID: 10801841
2. Cloning of MMP-26. A novel matrilysin-like proteinase.  |  de Coignac, AB., et al. 2000. Eur J Biochem. 267: 3323-9. PMID: 10824119
3. Matrilysin-2, a new matrix metalloproteinase expressed in human tumors and showing the minimal domain organization required for secretion, latency, and activity.  |  Uría, JA. and López-Otín, C. 2000. Cancer Res. 60: 4745-51. PMID: 10987280
4. Endometrial TIMP-4 mRNA is high at midcycle and in hyperplasia, but down-regulated in malignant tumours. Coordinated expression with MMP-26.  |  Pilka, R., et al. 2004. Mol Hum Reprod. 10: 641-50. PMID: 15273280
5. Matrix metalloproteinase-26 is associated with estrogen-dependent malignancies and targets alpha1-antitrypsin serpin.  |  Li, W., et al. 2004. Cancer Res. 64: 8657-65. PMID: 15574774
6. Matrilysins-1 and -2 (MMP-7 and -26) and metalloelastase (MMP-12), unlike MMP-19, are up-regulated in necrotizing enterocolitis.  |  Bister, V., et al. 2005. J Pediatr Gastroenterol Nutr. 40: 60-6. PMID: 15625428
7. Matrix metalloproteinases 21 and 26 are differentially expressed in esophageal squamous cell cancer.  |  Ahokas, K., et al. 2006. Tumour Biol. 27: 133-41. PMID: 16641547
8. Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor.  |  Lee, S., et al. 2006. Cell Res. 16: 750-8. PMID: 16940965
9. Increased expression of matrix metalloproteinases-21 and -26 and TIMP-4 in pancreatic adenocarcinoma.  |  Bister, V., et al. 2007. Mod Pathol. 20: 1128-40. PMID: 17873896