Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
mGluR-5 Antibody (1B3) is a high quality monoclonal mGluR-5 antibody (also designated GRM5 antibody, Glutamate Metabotropic Receptor 5 antibody, GPRC1E antibody, MGLUR5 antibody, Protein Phosphatase 1 Regulatory Subunit 86 antibody, Metabotropic Glutamate Receptor 5 antibody, PPP1R86 antibody, or MGlu5 antibody) suitable for the detection of the mGluR-5 protein of mouse, rat and human origin. mGluR-5 Antibody (1B3) is available as the non-conjugated anti-mGluR-5 antibody. The mGluR proteins (metabotropic Glutamate Receptors) are members of the G protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic Glutamate Receptors). The eight currently known mGluR proteins are mediated by two G proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR1 and mGluR5 are mediated by a G protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight sub-types of mGluR have an activity mediated by a G protein that inhibits adenylate cyclase activity. mGluR-5, which can interact with SIAH-1, RyR-1, RyR-2, ITPR1, Shank 1, Shank 3 and GRASP, acts as a receptor for glutamate. The PPXXf motif of mGluR-5 binds to HOM1, HOM2 and HOM3.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Rated 1 out of
not workingImmunostaining : used 1:50 dilution , no staining with rat striatal cultures
western:used 1: 250 dilution with wild type and knock out mGluR5 brain tissue--- no specific bands, quite a few non specific bands
Date published: 2017-10-20
Rated 1 out of
Did not work on mouse brainTried on mouse embryonic and P0 brain, this antibody did not detect any signal at 145KDa on western blot at concentration 1:300.