MCH-1R 抗体 (52-W7): sc-100327

MCH-1R Antibody (52-W7) is an IgG_2a κ mouse monoclonal MCH-1R antibody (also designated MCH-1R antibody) that detects the MCH-1R protein of human origin by WB, IP and ELISA. MCH-1R Antibody (52-W7) is available as the non-conjugated anti-MCH-1R antibody. Melanin-concentrating hormone (MCH) is a 19 amino acid cyclic neuropeptide, which is mainly expressed in the hypothalamus. MCH modulates feeding behavior, aggression, anxiety, arousal and reproductive function in mammals by controlling the release of luteinizing hormone (LH). The melanin-concentrating hormone receptor (MCHR, also designated SLC-1) is a glycosylated G-protein coupled receptor. MCHR mediates the effects of MCH through Gai and/or Gaq signaling and is expressed in several regions of the brain, including the cerebral cortex, amygdala, thalamus and hypothalamus (1,2,6). MCH and MCHR have also been implicated in stimulating leptin expression and secretion in adipocytes, which suggests that the melanin-concentrating hormone and its receptor may be potential targets for modulating obesity.

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References:

1. (D-(p-benzoylphenylalanine)13, tyrosine19)-melanin-concentrating hormone, a potent analogue for MCH receptor crosslinking.  |  Drozdz, R., et al. 1999. J Pept Sci. 5: 234-42. PMID: 10363906
2. Molecular characterization of the melanin-concentrating-hormone receptor.  |  Saito, Y., et al. 1999. Nature. 400: 265-9. PMID: 10421368
3. The influence of gonadal steroids on pre-pro melanin-concentrating hormone mRNA in female rats.  |  Murray, JF., et al. 2000. J Neuroendocrinol. 12: 53-9. PMID: 10692143
4. Melanin-concentrating hormone, melanocortin receptors and regulation of luteinizing hormone release.  |  Murray, JF., et al. 2000. J Neuroendocrinol. 12: 217-23. PMID: 10718917
5. The distribution of the mRNA and protein products of the melanin-concentrating hormone (MCH) receptor gene, slc-1, in the central nervous system of the rat.  |  Hervieu, GJ., et al. 2000. Eur J Neurosci. 12: 1194-216. PMID: 10762350
6. Melanin-concentrating hormone regulates leptin synthesis and secretion in rat adipocytes.  |  Bradley, RL., et al. 2000. Diabetes. 49: 1073-7. PMID: 10909960
7. The melanin-concentrating hormone receptor couples to multiple G proteins to activate diverse intracellular signaling pathways.  |  Hawes, BE., et al. 2000. Endocrinology. 141: 4524-32. PMID: 11108264