Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
MAN1B1 (mannosidase alpha, class 1B, member 1), also referred to as MANA-ER or ERManI, is a widely expressed enzyme that is a member of the glycosyl hydrolase 47 family. MAN1B1 is a single-pass type II membrane protein that localizes to the endoplasmic reticulum (ER) and catalyzes the first mannose trimming step in the maturation of Asn-linked oligosaccharide biosynthesis on glycoproteins. Asn-linked oligosaccharides are important for a variety of biological functions, including cellular recognition, adhesion and protein targeting. MAN1B1 is also involved in targeting terminally misfolded or unassembled glycoproteins for degradation via the cytoplasmic ubiquitin-proteasome pathway, a process known as endoplasmic reticulum-associated protein degradation (ERAD). MAN1B1 activity requires calcium and is inhibited by either 1-deoxymannojirimycin or kifunensine, which are class I alpha-mannosidase inhibitors.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.