MAN1B1 抗体 (30-Y): sc-100543

MAN1B1 (mannosidase alpha, class 1B, member 1), also referred to as MANA-ER or ERManI, is a widely expressed enzyme that is a member of the glycosyl hydrolase 47 family. MAN1B1 is a single-pass type II membrane protein that localizes to the endoplasmic reticulum (ER) and catalyzes the first mannose trimming step in the maturation of Asn-linked oligosaccharide biosynthesis on glycoproteins. Asn-linked oligosaccharides are important for a variety of biological functions, including cellular recognition, adhesion and protein targeting. MAN1B1 is also involved in targeting terminally misfolded or unassembled glycoproteins for degradation via the cytoplasmic ubiquitin-proteasome pathway, a process known as endoplasmic reticulum-associated protein degradation (ERAD). MAN1B1 activity requires calcium and is inhibited by either 1-deoxymannojirimycin or kifunensine, which are class I alpha-mannosidase inhibitors.