Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Lunatic Fringe Antibody (TT-07) is a high quality monoclonal Lunatic Fringe antibody (also designated Lunatic Fringe antibody) suitable for the detection of the Lunatic Fringe protein of mouse, rat and human origin. Lunatic Fringe Antibody (TT-07) is available as the non-conjugated anti-Lunatic Fringe antibody. Three mammalian fringe family members, namely Manic Fringe, Radical Fringe and Lunatic Fringe, have been identified as proteins related to Drosophila fringe, a protein involved in development. Fringe proteins act upstream of the Notch signaling pathway and are involved in boundary determination during segmentation. Each mammalian fringe displays different patterns of expression, though all are expressed in the mouse embryo as well as in many adult tissues. Lunatic Fringe, also known as LFNG or SCDO3, is a 379 amino acid single-pass type II membrane protein that localizes to the membrane of the Golgi apparatus. Functioning as a glycosyltransferase, Lunatic Fringe acts a critical mediator of somite patterning and segmentation and plays a fundamental role in initiating the elongation of O-linked fucose residues that are attached to Notch molecules. Defects in the gene encoding Lunatic Fringe are the cause of autosomal recessive spondylocostal dysostosis 3 (SCDO3), a disorder that arises during embryonic development and is characterized by rib anomalies and multiple vertebrate segmentation. Three isoforms of Lunatic Fringe are expressed due to alternative splicing events.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
For Western Blot, is it recommended to use denatured or non-denatured conditions with Lunatic Fringe (TT-07): sc-100756 antibody?
Asked by: Professor Griffin
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.