Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US, Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxesShips via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal health products, bulky and/or heavy items
LRRFIP1 (also designated GCF2) is an 738 amino acid human protein whose rodent counterpart is known as Lrrfip1 (also designated FLAP in mouse). LRRFIP1 is a transcriptional repressor which will preferentially bind to the GC-rich consensus sequence (5′-AGCCCCCGGCG-3′) and may also regulate expression of TNF, EGFR and PDGF-A. LRRFIP1 is also believed to control smooth muscle cell proliferation following arterial injury through PDGF-A repression. The N-terminus of LRRFIP1 shows high homology to the coiled-coil domain of FLAP, a protein which binds the leucine-rich repeat (LRR) of Flightless I, and the interaction of LRRFIP1 with the LRR of Flightless I has been confirmed. LRRFIP1 does not bind single-stranded DNA or RNA significantly and binds double-stranded DNA weakly. In contrast, LRRFIP1 binds double-stranded RNA with high affinity, and two molecules of LRRFIP1 bind the TaR stem. The RNA binding domain has been identified and encompasses a lysine-rich motif. Flightless I has a C-terminal TaR-like domain which binds Actin and therefore the association of LRRFIP1 with the LRR of Flightless I may provide a link between the Actin cytoskeleton and RNA in mammalian cells.
种属 | 基因名称 | 基因ID | 染色质位置 | 亚型(mRNA)即位号码 | 蛋白质即位号码 | OMIM™ 号码 |
---|---|---|---|---|---|---|
Human | LRRFIP1 | 9208 | 2q37.3 | XM_005246141, XM_005246142, XM_017005253, XM_017005254, XM_017005255, XM_017005256, XM_017005257, XM_017005258, XM_017005259, XM_017005260, XM_017005261, XM_017005262, XM_017005263, NM_001137550, NM_001137551, NM_001137552, NM_001137553, NM_004735 | Q32MZ4 | 603256 |