Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US, Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxesShips via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal health products, bulky and/or heavy items
LLGL2 (lethal giant larvae homolog 2), also referred to as HGL or LGL2, is a cortical cytoskeleton protein that is a part of a larger complex of proteins. The complex, which consists of LGN, PKC i and PAR-6β, may play a role in ensuring thecorrect organization and orientation of bipolar spindles for normal cell division and for the initial phase of the establishment of epithelial cell polarity. in Drosophila melanogaster, LLGL2 is required in follicle cells for the differentiation of both stalk cells and posterior follicle cells. In humans, LLGL2 may be involved in cell proliferation control and tumorigenesis. Phosphorylation of LLGL2 is induced during cell polarization and may contribute to the segregation of LLGL2 from the PKC i and PAR-6β complex. Overexpression of LLGL2 is thought to inhibit tight junction formation in cells. LLGL2 is expressed in the cytoplasm and localizes to the perinuclear structure of the cell.
种属 | 基因名称 | 基因ID | 染色质位置 | 亚型(mRNA)即位号码 | 蛋白质即位号码 | OMIM™ 号码 |
---|---|---|---|---|---|---|
Human | LLGL2 | 3993 | 17q25.1 | XM_011524801, XM_011524802, XM_011524807, XM_017024625, XM_017024626, XM_017024627, XM_017024628, XM_017024629, XM_017024630, XM_017024631, XM_017024632, NM_001015002, NM_001031803, NM_004524 | Q6P1M3 | n/a |