LGI4 抗体 (KT18): sc-101488

LGI4 Antibody (KT18) is an IgG₁ rat monoclonal LGI4 antibody (also designated LGI4 antibody) that detects the LGI4 protein of mouse origin by WB, IF and IHC(P). LGI4 Antibody (KT18) is available as the non-conjugated anti-LGI4 antibody. LGI4 (leucine-rich repeat LGI family member 4), also known as leucine-rich glioma-inactivated protein 4, is a 537 amino acid secreted glycosylated protein that is widely expressed, with highest levels found within the nervous system. Interestingly, siRNA knockdown studies of LGI4 expression in Schwann cells have been shown to result in the inhibition of myelination, thus suggesting that LGI4 is an essential component of myelin formation and axon segregation. LGI4 shares significant homology with its other family members, LGI1, LGI2 and LGI3. Significantly, mutations in the gene encoding LGI1 have been linked to human temporal lobe epilepsy and, given the sequence similarity of LGI4, it is likely that it also may be implicated in the pathology of seizures. LGI4 is localized subcellularly to the Golgi, ER and vesicles. There are two isoforms of LGI4 that are produced as a result of alternative splicing events.

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References:

1. The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins.  |  Gu, W., et al. 2002. FEBS Lett. 519: 71-6. PMID: 12023020
2. A common protein interaction domain links two recently identified epilepsy genes.  |  Scheel, H., et al. 2002. Hum Mol Genet. 11: 1757-62. PMID: 12095917
3. The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders.  |  Staub, E., et al. 2002. Trends Biochem Sci. 27: 441-4. PMID: 12217514
4. ADPEAF mutations reduce levels of secreted LGI1, a putative tumor suppressor protein linked to epilepsy.  |  Senechal, KR., et al. 2005. Hum Mol Genet. 14: 1613-20. PMID: 15857855
5. Using gene-history and expression analyses to assess the involvement of LGI genes in human disorders.  |  Gu, W., et al. 2005. Mol Biol Evol. 22: 2209-16. PMID: 16014869
6. The claw paw mutation reveals a role for Lgi4 in peripheral nerve development.  |  Bermingham, JR., et al. 2006. Nat Neurosci. 9: 76-84. PMID: 16341215
7. Genetic polymorphisms and idiopathic generalized epilepsies.  |  Lucarini, N., et al. 2007. Pediatr Neurol. 37: 157-64. PMID: 17765802
8. LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11.  |  Sagane, K., et al. 2008. Int J Biol Sci. 4: 387-96. PMID: 18974846