KIF15 抗体 (36-I): sc-100948

KIF15 Antibody (36-I) is an IgG_2b κ mouse monoclonal KIF15 antibody suitable for the detection of the KIF15 protein of human origin by WB, IP and ELISA. KIF15 Antibody (36-I) is available as the non-conjugated anti-KIF15 antibody. The kinesins constitute a large family of microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events including endocytosis and transcytosis. KIF15 (kinesin family member 15), also known as HKLP2 (human kinesin-like protein 2) or KNSL7, is a 1,388 amino acid kinesin-related protein that shares 53% amino acid identity with the Xenopus protein Xklp2, a plus-end directed kinesin-like motor. Based on similarity with Xklp2 and cellular localization, KIF15 is believed play a role in the crosslinking and immobilization of spindle microtubules. In mitotic cells, during prometaphase to early anaphase, KIF15 localizes to spindle poles and microtubules; during cytokinesis, KIF15 can be found at the actin-based cleavage furrow. In postmitotic neurons, KIF15 exclusively localizes to microtubules.

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References:

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