JRKL 抗体 (73-Q): sc-100971

The tigger transposable element derived (TIGD) protein family (whose members include TIGD1, TIGD2, TIGD3, TIGD4, TIGD5, TIGD6, TIGD7, JRKL and JRK) is a subfamily of the DNA-mediated transposons superfamily. While the exact function of tigger subfamily proteins is unknown, all tigger subfamily proteins contain a DDE domain and an HTH CENPB-type DNA-binding domain, indicating a possible DNA-binding function. JRKL is a 442 amino acid protein with a predicted nuclear localization. JRKL is abundantly expressed in most tissues, with less expression in liver, lung and peripheral blood leukocytes. With 35% homology to mouse JRK protein which causes epileptic seizures in mice when inactivated, JRKL may be biologically significant in the development of epilepsy.