Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
ITM1 (integral membrane protein 1), also known as TMC (transmembrane protein TMC) or STT3A (STT3, subunit of the oligosaccharyltransferase complex, homolog A), is a member of the STT3 family of proteins. Predominantly expressed in liver, pancreas, muscle, placenta and skin fibroblasts, ITM1 is a multi-pass membrane protein that localizes to the membrane of the endoplasmic reticulum (ER). ITM1 is one of two multicellular eukaryotic homologs of the S. cerevisiae protein Stt3, an essential component of the yeast OST (oligosaccharyltransferase) complex. Both homologs (ITM1 and SIMP) are glycosylated and function as the catalytic component of the mammalian OST complex which is responsible for catalyzing the transfer of a high mannose oligosaccharide to an asparagine residue in nascent proteins that enter the lumen of the ER. Using lipid-linked oligosaccharides as donors, the OST complex specifically transfers the oligosaccharide to the asparagine residue in an Asn-X-Ser/Thr consensus motif (X is any amino acid excluding proline). Compared with SIMP, ITM1 is less active but also more selective in terms of substrates.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Can sc-100796: ITM1 (JA-07) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?
Asked by: Randy McDonald
Thank you for your question. Yes, sc-100796: ITM1 (JA-07) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here:
Rated 4 out of
Produced wonderful immunoperoxidase cytoplasmicProduced wonderful immunoperoxidase cytoplasmic staining in formalin-fixed, paraffin-embedded human salivary gland tissue. -SCBT QC