Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
The interleukin-1 receptor-associated kinases (IRAKs) are important downstream signaling components of Toll-like receptors (TLRs). Four mammalian IRAKs have been found, namely IRAK-1, IRAK-2, IRAK-4, and IRAK-M, all of which share sequence homology to the Drosophila melanogaster protein kinase Pelle, and all contain a death domain (DD). The DD is used for protein-protein interactions with the DDs of other molecules, IRAK2 uses its DD to mediate its interaction with MyD88. The IRAKs have putative kinase domains, although IRAK1 has dispensable kinase activity because interleukin-1-induced NF-B activation could still be driven by a kinase-inactive mutant.Due to the absence of certain key residues within their putative kinase domains, both IRAK2 and IRAK-M are catalytically inactive.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Can sc-100388: IRAK-2 (R-Q6) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?
Asked by: TinTin
Thank you for your question. Yes, sc-100388: IRAK-2 (R-Q6) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here:
Rated 4 out of
Clear immunoperoxidase membrane and cytoplasmicClear immunoperoxidase membrane and cytoplasmic staining in formalin-fixed, paraffin-embedded human transitional cell carcinoma tissue. -SCBT QC
Date published: 2015-04-24
Rated 5 out of
CleanClean, crisp band seen in WB using K-562 whole cell lysate. -SCBT QC