Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Two forms of interleukin-1, designated IL-1α and IL-1β, have been described. Although encoded by distinct genes and exhibiting roughly only 25% sequence identity, IL-1α and IL-1β bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation, but it has also been shown to be expressed during kidney development, thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation acting as an activator of T and B lymphocytes and natural killer (NK) cells. IL-1 receptor antagonist (IL-1ra) is a cytokine that inhibits IL-1α and IL-1β binding to interleukin receptors. By neutralizing the activity of IL-1, IL-1ra contributes to the inhibition of the immune and inflammatory responses and has been targeted as a drug for the treatment of severely active rheumatoid arthritis. There are four isoforms of IL-1ra that are produced as a result of alternative splicing events.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Thank you for your question. We do not currently offer this specific antibody, sc-101616: IL-1ra (6A8), in a sample size. However, we do offer a free 10 µg sample of our recommended alternative clone to this same target, sc-374084: IL-1ra (A-4). A link to the antibody is below.
Please contact our Technical Service Department if you would like to request a free sample. Please call us toll-free at (800) 457-3801 option 2, e-mail <[email protected]>, or use the live chat on our website.
If you choose to purchase the 6A8 antibody, and it does not work for you in any of the recommended applications, please contact our Technical Service Department and we would be happy to assist you in troubleshooting the antibody. If it still does not work, then we can issue you a credit or a refund for your original purchase.
Answered by: Technical Support
Date published: 2017-05-24
For Western Blot, is it recommended to use denatured or non-denatured conditions with IL-1ra (6A8): sc-101616 antibody?
Asked by: jenni
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
I bought this antibody. And I expressed this protein in E.coli. But the purified protein could not be detected by western blotting using this antibody. Could you give me some suggestions?