HSP90 抗体 (AC-16): sc-101494

HSP 90 Antibody (AC-16) is an IgG1 κ mouse monoclonal HSP 90 antibody (also designated HSP 90 antibody or HSP90 antibody) that detects the constitutive and inducible forms of HSP90 of mouse, rat and human origin by WB and ELISA. HSP 90 Antibody (AC-16) is available as the non-conjugated anti-HSP 90 antibody form, as well as multiple conjugated forms of anti-HSP 90 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor^® conjugates. The heat shock response was first described for Drosophila salivary gland cells and morphologically consists of a change in their polytene chromosome puffing patterns that involves de novo synthesis of a few proteins. Similar heat shock proteins were later discovered in bacterial chicken and mammalian cells, and have been subsequently studied in other organisms. A series of proteins, including HSP 90, HSP 70, HSP 20-30 and ubiquitin, are induced by insults such as temperature shock, chemicals and other environmental stress. A major function of HSP 90 and other HSPs is to act as molecular chaperones. HSP 90 forms a complex with glucocorticoid receptor (GR), rendering the non ligand-bound receptor transcriptionally inactive. HSP 90 binds the GR as a heterocomplex composed of either HSP 56 or Cyclophilin D, forming an aporeceptor complex. HSP 90 also exists as a dimer with other proteins such as p60/STI1 and p23, forming an apo-receptor complex with estrogen and androgen receptors.

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