Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
HMGCL Antibody (63Z) is a high quality monoclonal HMGCL antibody (also designated HMGCL antibody) suitable for the detection of the HMGCL protein of human origin. HMGCL Antibody (63Z) is available as the non-conjugated anti-HMGCL antibody. HMGCL (3-hydroxy-3-methylglutaryl-Coenzyme A (CoA) lyase), also known as HMG-CoA lyase or HL, is a mitochondrial matrix protein that belongs to the HMG-CoA lyase family of proteins. Expressed in liver, lymphoblasts and fibroblasts, HMGCL exists as a homodimer and participates in leucine catabolism and ketogenesis, the hepatic synthesis of ketone bodies that, during fasting, provide a major source of energy for heart, brain and kidney. More specifically, HMGCL catalyzes the final step of these processes, the cleavage of 3-hydroxy-3-methylglutaryl CoA to acetoacetic acid and acetyl CoA. Mutations in the gene encoding HMGCL can lead to HMG-CoA lyase deficiency (also known as HL deficiency or hydroxymethylglutaricaciduria), a metabolic disease that, if left untreated, results in hypoglycemia and coma.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
For Western Blot, is it recommended to use denatured or non-denatured conditions with HMGCL (63Z): sc-100548 antibody?
Asked by: AbPolly
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.