HERP 抗体 (19-Y): sc-100721

HERP Antibody (19-Y) is an IgG_2a κ mouse monoclonal HERP antibody (also designated HERP antibody) that detects the HERP protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. HERP Antibody (19-Y) is available as the non-conjugated anti-HERP antibody. The endoplasmic reticulum (ER) stress response is triggered by the accumulation of unfolded proteins within the ER and is characterized by three events: the inhibition of translation (to prevent further protein accumulation), the up-regulated expression of polypeptide-folding proteins (known as the unfolded protein response, or UPR) and the degradation of misfolded proteins by the ER-associated protein degradation (ERAD) system. HERP, also known as HERPUD1 (homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1), SUP or MIF1, is a 391 amino acid multi-pass membrane protein that localizes to the ER and contains one N-terminal ubiquitin-like domain. Widely expressed with highest expression in the brain, HERP is a component of the ERAD system and, via its ubiquitin-like domain, is thought to be involved in the destruction of misfolded proteins. Three isoforms of HERP exist due to alternative splicing events.

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References:

1. The novel MMS-inducible gene Mif1/KIAA0025 is a target of the unfolded protein response pathway.  |  van Laar, T., et al. 2000. FEBS Lett. 469: 123-31. PMID: 10708769
2. Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress.  |  Kokame, K., et al. 2000. J Biol Chem. 275: 32846-53. PMID: 10922362
3. Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response.  |  Kokame, K., et al. 2001. J Biol Chem. 276: 9199-205. PMID: 11112790
4. Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein.  |  Sai, X., et al. 2002. J Biol Chem. 277: 12915-20. PMID: 11799129
5. The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway.  |  Schulze, A., et al. 2005. J Mol Biol. 354: 1021-7. PMID: 16289116
6. Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element.  |  Liang, G., et al. 2006. Mol Cell Biol. 26: 7999-8010. PMID: 16940180
7. The ubiquitin E3 ligase POSH regulates calcium homeostasis through spatial control of Herp.  |  Tuvia, S., et al. 2007. J Cell Biol. 177: 51-61. PMID: 17420289
8. Characterization of an ERAD pathway for nonglycosylated BiP substrates, which require Herp.  |  Okuda-Shimizu, Y. and Hendershot, LM. 2007. Mol Cell. 28: 544-54. PMID: 18042451
9. Herp enhances ER-associated protein degradation by recruiting ubiquilins.  |  Kim, TY., et al. 2008. Biochem Biophys Res Commun. 369: 741-6. PMID: 18307982