Herc3 抗体 (37.2): sc-100720

Herc3 Antibody (37.2) is an IgG₁ κ mouse monoclonal Herc3 antibody (also designated Herc3 antibody) that detects the Herc3 protein of human origin by IF, IHC(P) and ELISA. Herc3 Antibody (37.2) is available as the non-conjugated anti-Herc3 antibody. Herc3 (HECT domain and RCC1-like domain-containing protein 3) is a 1,050 amino acid protein that localizes to both the cytoplasm and to vesicular-like structures. Involved in protein degradation pathways, Herc3 functions as an E3 ubiquitin ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfers that residue to a protein that is targeted for degradation. Herc3, like other members of the Herc family, contains one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and seven RCC1 repeats through which is conveys its E3 ubiquitin ligase activity. Upon ubiquitination, Herc3 is targeted for proteasomal degradation.

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References:

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2. The human HERC3 gene maps to chromosome 4q21 by fluorescence in situ hybridization.  |  Cruz, C., et al. 1999. Cytogenet Cell Genet. 87: 263-4. PMID: 10702688
3. The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects.  |  Hochrainer, K., et al. 2005. Genomics. 85: 153-64. PMID: 15676274
4. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.  |  Nomura, N., et al. 1994. DNA Res. 1: 27-35. PMID: 7584026