Hck 抗体 (3D12E10): sc-101428

Hck Antibody (3D12E10) is a high quality monoclonal Hck antibody (also designated HCK Proto-Oncogene antibody, Src Family Tyrosine Kinase antibody, Tyrosine-Protein Kinase HCK antibody, Hematopoietic Cell Kinase antibody, P59-HCK/P60-HCK antibody, P59Hck antibody, P61Hck antibody, or JTK9 antibody) suitable for the detection of the Hck protein of mouse, rat and human origin. Hck Antibody (3D12E10) is available as both the non-conjugated anti-Hck antibody form, as well as multiple conjugated forms of anti-Hck antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor^® conjugates. Src is the human homolog of the v-src gene of the Rous sarcoma virus, also called avian sarcoma virus or ASV. Src was the first proto-oncogenic non-receptor tyrosine kinase characterized in human. By virtue of common structural motifs, the Src family is composed of nine members in vertebrates, including Src, Yes, Fgr, Frk, Fyn, Lyn, Hck, Lck and Blk. Src-family kinases transduce signals that are involved in the control of a variety of cellular processes, including proliferation, differentiation, motility and adhesion. Src family kinases contain an amino terminal cell membrane anchor followed by an SH3 domain and an SH2 domain involved in modular association and activation, respectively. Src family kinases are normally maintained in an inactive state and can be activated transiently during cellular events such as mitosis. Different subcellular localizations of Src family kinases may be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization and membrane trafficking. The human hemopoietic cell kinase (Hck) gene maps to chromosome 20q11-q12 and encodes a 505 amino acid protein. The Hck protein is expressed in hematopoietic cells, and is particularly abundant in granulocytes.

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