GSDML 抗体 (3D8): sc-101239

GSDML Antibody (3D8) is an IgG_2b κ mouse monoclonal GSDML antibody (also designated GSDML antibody) that detects the GSDML protein of human origin by WB, IP and ELISA. GSDML Antibody (3D8) is available as the non-conjugated anti-GSDML antibody. GSDML (gasdermin-like), also known as GSDMB, PP4052 or PRO2521, is a member of the GSDMDC (gasdermin-domain containing) family of proteins. Members of the GSDMDC family are involved in a wide variety of cellular processes, including cell-cycle control, extracellular matrix production, differentiation and apoptosis, and have been associated with the development and progression of cancer. GSDML is a widely expressed protein found in both cancerous and non-cancerous tissues localizing to the cytoplasm and in secretory vesicles. The gene encoding GSDML is thought to have been generated by a duplication event of the GSDM1 gene which encodes gasdermin. In addition, various isoforms exist for GSDML.

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References:

1. Evolutionary recombination hotspot around GSDML-GSDM locus is closely linked to the oncogenomic recombination hotspot around the PPP1R1B-ERBB2-GRB7 amplicon.  |  Katoh, M. and Katoh, M. 2004. Int J Oncol. 24: 757-63. PMID: 15010812
2. Identification and characterization of human DFNA5L, mouse Dfna5l, and rat Dfna5l genes in silico.  |  Katoh, M. and Katoh, M. 2004. Int J Oncol. 25: 765-70. PMID: 15289881
3. Transcriptional control of the HERV-H LTR element of the GSDML gene in human tissues and cancer cells.  |  Sin, HS., et al. 2006. Arch Virol. 151: 1985-94. PMID: 16625320
4. [Progress of researches on gene function of GSDMDC family].  |  Sun, Q., et al. 2006. Yi Chuan. 28: 596-600. PMID: 16735241
5. Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner.  |  Tamura, M., et al. 2007. Genomics. 89: 618-29. PMID: 17350798
6. Identification of a predictive gene expression signature of cervical lymph node metastasis in oral squamous cell carcinoma.  |  Nguyen, ST., et al. 2007. Cancer Sci. 98: 740-6. PMID: 17391312
7. Differential expression and localisation of gasdermin-like (GSDML), a novel member of the cancer-associated GSDMDC protein family, in neoplastic and non-neoplastic gastric, hepatic, and colon tissues.  |  Carl-McGrath, S., et al. 2008. Pathology. 40: 13-24. PMID: 18038310