γD-crystallin 抗体 (SB-18): sc-100697

γD-crystallin Antibody (SB-18) is an IgG₁ κ mouse monoclonal gamma D-crystallin antibody (also designated γD-crystallin antibody) that detects the gamma D-crystallin protein of mouse, rat and human origin by WB, IP and ELISA. γD-crystallin Antibody (SB-18) is available as the non-conjugated anti-gamma D-crystallin antibody. Crystallins are the major proteins of the vertebrate eye lens, where they maintain the transparency and refractive index of the lens. Crystallins are divided into α, β, and γ families, and the β and γ-crystallins also comprise a superfamily. Crystallins usually contain seven distinctive protein regions, including four homologous motifs, a connecting peptide, and N- and C-terminal extensions. γ-crystallins are structural proteins in the lens, and they exists as monomers which typically lack connecting peptides and terminal extensions. The γ-crystallins include seven closely related proteins, namely γA-, γB-, γC-, γD-, γE-, γF-, and γG-crystallin, as well as the γN and γS-crystallin proteins. The γ-crystallins are differentially regulated after early development, and are involved in cataract formation as a result of either age-related protein degradation or genetic mutation.

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References:

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3. Expression and regulation of alpha-, beta-, and gamma-crystallins in mammalian lens epithelial cells.  |  Wang, X., et al. 2004. Invest Ophthalmol Vis Sci. 45: 3608-19. PMID: 15452068
4. Regulation of expression within a gene family. The case of the rat gammaB- and gammaD-crystallin promoters.  |  Klok, EJ., et al. 1998. J Biol Chem. 273: 17206-15. PMID: 9642290
5. Purification of gamma-crystallin from human lenses by acetone precipitation method.  |  Srivastava, OP. and Srivastava, K. 1998. Curr Eye Res. 17: 1074-81. PMID: 9846626
6. Degradation of gamma D- and gamma s-crystallins in human lenses.  |  Srivastava, OP. and Srivastava, K. 1998. Biochem Biophys Res Commun. 253: 288-94. PMID: 9878530
7. Progressive juvenile-onset punctate cataracts caused by mutation of the gammaD-crystallin gene.  |  Stephan, DA., et al. 1999. Proc Natl Acad Sci U S A. 96: 1008-12. PMID: 9927684