Fc ε RIα 抗体 (X-22): sc-100279

Fc ε RIα Antibody (X-22) is an IgG₁ κ mouse monoclonal Fc epsilon RI alpha antibody (also designated Fc ε RIα antibody) that detects the Fc epsilon RI alpha protein of human origin by WB, IP and ELISA. Fc ε RIα Antibody (X-22) is available as the non-conjugated anti-Fc epsilon RI alpha antibody. IgE Fc Receptor I binds to the Fc region of immunoglobulin e chain with high affinity, and is responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators such as histamines, responsible for the manifestations of allergy. IgE Fc Receptor I also induces the secretion of important lymphokines, effectors of the hypersensitivity response. Receptor I is a tetramer of a heavily glycosylated α chain (Fc ε RIα), β chain and two disulfide linked γ chains. Fc ε RIα is exposed to the outer surface of the cell and contains the IgE binding site. Expression of IgE Fc RI mRNA appears to be highly specific and has been identified in mast cells and IL-3 dependent myeloid-monocyte precursor. Alternative splicing of the genomic transcript for the a chain has also been identified.

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References:

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