m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred detection reagent for FANCM Antibody (M40-P2C6) for WB applications. This reagent is now offered in a bundle with FANCM Antibody (M40-P2C6) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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FANCM Antibody (M40-P2C6) is a high quality monoclonal FANCM antibody (also designated FANCM antibody) suitable for the detection of the FANCM protein of human origin. FANCM Antibody (M40-P2C6) is available as both the non-conjugated anti-FANCM antibody form, as well as multiple conjugated forms of anti-FANCM antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromosomal instability. At the cellular level, FA is characterized by spontaneous chromosomal breakage and a unique hypersensitivity to DNA cross-linking agents. The thirteen FA proteins that have been characterized are important for regulating chromosomal stability and genome surveillance. Eight of these proteins, namely FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL and FANCM, comprise the FA core complex, which catalyzes a key reaction in DNA repair: the monoubiquitination of FANCD2. FANCM (Fanconi anemia, complementation group M) is a member of the DEAD-box helicase family of proteins and contains a DEAH helicase domain and a nuclease domain. Localizing to chromatin fractions, FANCM is phosphorylated in a cell cycle-dependent manner and is believed to function as an anchor, recruiting the FA core complex to chromatin. Mutations in the gene encoding FANCM can lead to Fanconi anemia.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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