ERM 抗体 (H-06): sc-100941

ERM Antibody (H-06) is an IgG₁ κ mouse monoclonal ERM antibody (also designated ETS Variant Transcription Factor 5 antibody, ERM antibody, ETS Translocation Variant 5 antibody, Ets-Related Protein ERM antibody, Ets-Related Molecule antibody, ETS Variant 5 antibody, or Ets Variant Gene 5 (Ets-Related Molecule) antibody) that detects the ERM protein of mouse, rat and human origin by WB, IP and ELISA. ERM Antibody (H-06) is available as the non-conjugated anti-ERM antibody. Ets-1 is the prototype member of a family of genes identified on the basis of homology to the v-Ets oncogene isolated from the E26 erythroblastosis virus. This family of genes includes Ets-1, Ets-2, Erg-1-3, Elk-1, Elf-1, Elf-5, NERF, PU.1, PEA3, ERM, FEV, ER8l, Fli-1, TEL, Spi-B, ESE-1, ESE-3A, Net, ABT1 and ERF. Members of the Ets gene family share a highly conserved carboxy terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. This conserved domain is essential for Ets-1 binding to DNA and is likely to be responsible for the DNA binding activity of all members of the Ets gene family. Several of these proteins have been shown to recognize similar motifs in DNA that share a centrally located 5′-GGAA-3′ element.

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References:

1. Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells.  |  Xin, JH., et al. 1992. Genes Dev. 6: 481-96. PMID: 1547944
2. Biochemical properties and cellular localisation of STIM proteins.  |  Dziadek, MA. and Johnstone, LS. 2007. Cell Calcium. 42: 123-32. PMID: 17382385
3. ERM is expressed by alveolar epithelial cells in adult mouse lung and regulates caveolin-1 transcription in mouse lung epithelial cell lines.  |  Kathuria, H., et al. 2007. J Cell Biochem. 102: 13-27. PMID: 17390339
4. Ligation of membrane Ig leads to calcium-mediated phosphorylation of the proto-oncogene product, Ets-1.  |  Fisher, CL., et al. 1991. J Immunol. 146: 1743-9. PMID: 1900874
5. elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints.  |  Rao, VN., et al. 1989. Science. 244: 66-70. PMID: 2539641
6. Identification and preferential expression in thymic and bursal lymphocytes of a c-ets oncogene-encoded Mr 54,000 cytoplasmic protein.  |  Ghysdael, J., et al. 1986. Proc Natl Acad Sci U S A. 83: 1714-8. PMID: 3006066
7. The erg gene: a human gene related to the ets oncogene.  |  Reddy, ES., et al. 1987. Proc Natl Acad Sci U S A. 84: 6131-5. PMID: 3476934
8. A variant Ewing′s sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1.  |  Jeon, IS., et al. 1995. Oncogene. 10: 1229-34. PMID: 7700648
9. Molecular cloning and characterization of human ERM, a new member of the Ets family closely related to mouse PEA3 and ER81 transcription factors.  |  Montε, D., et al. 1994. Oncogene. 9: 1397-406. PMID: 8152800