Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
ERBIN Antibody (10D2) is a high quality monoclonal ERBIN antibody (also designated ERBIN antibody) suitable for the detection of the ERBIN protein of mouse, rat and human origin. ERBIN Antibody (10D2) is available as the non-conjugated anti-ERBIN antibody. The ErbB-2 receptor tyrosine kinase evolved as a shared coreceptor of all ErbB-specific growth factors and acts as a coordinator of a variety of biological signaling networks. ErbB-2 couples ErbB receptors to the migration/invasion machinery of carcinoma cells by employing adaptor proteins, such as p130CAS and c-CrkII, which regulate the actin-myosin cytoskeleton of migratory cells. ErbB-2 is expressed in basal cells of sqamous epithelia and is important in the morphogenesis and oncogenesis of secretory epithelia. In epithelia, ErbB-2 employs the adaptor protein ERBIN (ErbB-2 interacting protein), which functions in the localization and signaling of ErbB-2. ERBIN contains a PDZ domain that directly and specifically interacts with ErbB-2, causing ERBIN and ErbB-2 to colocalize to the lateral membrane of intestinal epithelial cells. ERBIN provides further evidence to support the claim that the tumorigenic action of ErbB-2 may be attributed to its ability to acts as a shared signaling subunit, rather than functioning as a distinct receptor.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.