Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
ENC1 Antibody (SS-9) is a high quality monoclonal ENC1 antibody (also designated ENC1 antibody) suitable for the detection of the ENC1 protein of human origin. ENC1 Antibody (SS-9) is available as the non-conjugated anti-ENC1 antibody. Proteolytic degradation by the ubiquitin (Ub) system is essential for normal cell cycle progression, cellular differentiation and stress responses. The E3 ubiquitin-protein ligase complex uses a substrate-specific adapter, ENC1 (Ectoderm-neural cortex protein 1), to mediate ubiquitination. ENC1, also known as NRPB or PIG10, is a 589 amino acid Actin-binding protein that is involved in differentiation of neural crest cells and regulation of neuronal process formation. ENC1 is localized to the nuclear matrix and is highly expressed in adult brain and spinal cord tissues. Expression of ENC1 is up-regulated during neuronal differentiation. ENC1 may be regulated by the β-catenin/TCF pathway and is thought to play a role in histogenesis. ENC1 interacts with hypophosphorylated Rb (Retinoblastoma-associated protein) to form a complex that contains CUL-3, Rbx1 and ENC1 which is essential for neuronal cell differentiation. ENC1 contains one BTB (POZ) domain and six Kelch repeats. The BTB domain is thought to be necessary for the protein-protein interactions involved in cytoskeletal organization and the Kelch repeats denote a conserved tertiary structure. ENC1 is highly expressed in brain tumors, suggesting a possible role in carcinogenesis.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.