EHD3 抗体 (RR-L): sc-100723

EHD3 Antibody (RR-L) is an IgG₁ κ mouse monoclonal EHD3 antibody (also designated EHD3 antibody) that detects the EHD3 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. EHD3 Antibody (RR-L) is available as the non-conjugated anti-EHD3 antibody. The Eps15 homology (EH) domain-containing protein family consists of four members, EHD1, EHD2, EHD3, and EHD4. The chromosomal locations of the human EHD genes are as follows: EHD1 maps to 11q13, EHD2 maps to 19q13.3, EHD3 maps to 2p21, and EHD4 maps to 15q11.1 (1-3). The encoded proteins of all EHD family members contain multiple conserved regions, which include an amino-terminal nucleotide-binding consensus site, a bipartite nuclear localization signal, and a carboxy-terminal EH protein-binding domain with an EF-hand motif (3,4). EHD1 is ubiquitously expressed with increased expression in testis (2,3). EHD2, EHD3, and EHD4 have more specific expression with EHD2 highly expressed in heart, EHD3 expressed in brain, kidney, liver, placenta, ovary, and heart, and EHD4 expressed in heart, placenta, and pancreas (1,5,6). The EHD proteins may participate in ligand-induced endocytosis (3-5).

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References:

1. EHD1--an EH-domain-containing protein with a specific expression pattern.  |  Mintz, L., et al. 1999. Genomics. 59: 66-76. PMID: 10395801
2. Evaluation and molecular characterization of EHD1, a candidate gene for Bardet-Biedl syndrome 1 (BBS1).  |  Haider, NB., et al. 1999. Gene. 240: 227-32. PMID: 10564830
3. EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins.  |  Pohl, U., et al. 2000. Genomics. 63: 255-62. PMID: 10673336
4. Characterization of EHD4, an EH domain-containing protein expressed in the extracellular matrix.  |  Kuo, HJ., et al. 2001. J Biol Chem. 276: 43103-10. PMID: 11533061
5. A tubular EHD1-containing compartment involved in the recycling of major histocompatibility complex class I molecules to the plasma membrane.  |  Caplan, S., et al. 2002. EMBO J. 21: 2557-67. PMID: 12032069
6. EHD3: a protein that resides in recycling tubular and vesicular membrane structures and interacts with EHD1.  |  Galperin, E., et al. 2002. Traffic. 3: 575-89. PMID: 12121420