EHD2 抗体 (L-05): sc-100724

Eps15 homology domain (EHD)-containing proteins function in the exit of receptors and other membrane proteins from the endosomal recycling compartment. EHD2 (EH-domain containing 2), also known as PAST2, is a 543 amino acid protein that contains one EF-hand domain and one EH domain. Expressed at high levels in heart and at lower levels in lung, placenta and skeletal muscle, EHD2 interacts with various proteins such as the glucose transporter Glut4 and the endocytotic-associated protein EHBP1. When EHD2 associates with insulin-induced Glut4, it can recruit Glut4 to the plasma membrane, thereby allowing Glut4 to bind glucose and regulate blood sugar levels. Additionally, EHD2 interacts with EHBP1 and is thought to link EHBP1-associated endocytotic events with actin cytoskeleton dynamics. Through its interactions with these two proteins, EHD2 is involved in both maintaining blood glucose levels and mediating actin-associated endocytosis.