EBV LMP-2A 抗体 (4E11): sc-101316

Epstein-Barr virus (EBV) is a human herpesvirus that ubiquitously infects the majority of the human population. Although most EBV infections are asymptomatic, the virus itself is associated with epithelioid and lymphoid malignancies. EBV LMP-2A (Epstein-Barr virus latent membrane protein 2A), also known as LMP2A, is a 497 amino acid EBV protein that exists on the surface of EBV-infected cells and consists of a short C-terminal tail, 12 membrane-spanning domains and a long N-terminal segment. Expressed in most EBV-associated malignancies, EBV LMP-2A associates with protein tyrosine kinases and, via this association, activates the PI 3-kinase (phosphatidylinositol 3-kinase) pathway, thereby preventing apoptosis. Through its ability to regulate PI 3-kinase signaling events, EBV LMP-2A provides growth and developmental survival signals to infected cells, thus facilitating EBV-induced tumorigenesis. Additionally, EBV LMP-2A can mimic B-cell receptor complex (BCR) signaling in BCR-negative cells, further implicating EBV LMP-2A as an important factor in the survival of mutated cells.