Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
EBV LMP-2A Antibody (15F9) is a high quality monoclonal EBV LMP-2A antibody (also designated Human herpesvirus 4 LMP2A antibody, Latent Membrane Protein 2A (LMP2A) antibody, LMP2A transmembrane protein antibody, HHV-4 LMP2A antibody, or Epstein-Barr virus antibody) suitable for the detection of the EBV LMP-2A protein of EBV origin. EBV LMP-2A Antibody (15F9) is available as both the non-conjugated anti-EBV LMP-2A antibody form, as well as multiple conjugated forms of anti-EBV LMP-2A antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Epstein-Barr virus (EBV) is a human herpesvirus that ubiquitously infects the majority of the human population. Although most EBV infections are asymptomatic, the virus itself is associated with epithelioid and lymphoid malignancies. EBV LMP-2A (Epstein-Barr virus latent membrane protein 2A), also known as LMP2A, is a 497 amino acid EBV protein that exists on the surface of EBV-infected cells and consists of a short C-terminal tail, 12 membrane-spanning domains and a long N-terminal segment. Expressed in most EBV-associated malignancies, EBV LMP-2A associates with protein tyrosine kinases and, via this association, activates the PI 3-kinase (phosphatidylinositol 3-kinase) pathway, thereby preventing apoptosis. Through its ability to regulate PI 3-kinase signaling events, EBV LMP-2A provides growth and developmental survival signals to infected cells, thus facilitating EBV-induced tumorigenesis. Additionally, EBV LMP-2A can mimic B-cell receptor complex (BCR) signaling in BCR-negative cells, further implicating EBV LMP-2A as an important factor in the survival of mutated cells.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Can EBV LMP-2A (15F9): sc-101315 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?
Asked by: Dr Ninau Qelp
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, EBV LMP-2A (15F9): sc-101315 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.