DS2 a positive allosteric modulator of δ-subunit containing GABAA receptors (EC50 = 142 nM for α4β3δ receptors). Has been shown to display no effects on GABA responses mediated by α4β3γ2 and α1β3γ2 receptors.
Wafford et al (2009) Novel compounds selectively enhance d subunit containing GABAA receptors and increase tonic currents in thalamus. Neuropharmacology 56 182.