Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Dynamin-related protein 1 (DRP1) mediates outer mitochondrial membrane fission in mammalian cells. DRP1 is also known as Dynamin-like protein 1, (Dlp1), DVLP or Dymple. DRP1 contains the N-terminal tripartite GTP-binding domain characteristic of the Dynamin superfamily of GTPases. DRP1 exists as a T-shaped dimer which contains a head, leg and stalk. The addition of GTP induces a rearrangement of the head and stalk that generates a force that ultimately results in membrane constriction. DRP1 is ubiquitously expressed with abundant expression in skeletal muscle, heart, kidney and brain. In the cell, DRP1 localized to the perinuclear region. In mouse brain, DRP1 is highly expressed in the cerebellum with particularly high levels in cerebellar Purkinje cells. During apoptosis, DRP1 translocates from the cytosol to mitochondria and localizes to potential sites of organelle division. Cell death is averted upon DRP inhibition, suggesting a critical role for mitochondrial fission in apoptosis.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.