DOCK 4 抗体 (R6Y): sc-100718

DOCK 4 Antibody (R6Y) is an IgG_2b κ mouse monoclonal DOCK 4 antibody (also designated DOCK 4 antibody) suitable for the detection of the DOCK 4 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. DOCK 4 Antibody (R6Y) is available as the non-conjugated anti-DOCK 4 antibody. DOCK 4 (Dedicator of cytokinesis protein 4) is a cytoplasmic peripheral membrane protein that belongs to the DOCK family of cytokinesis-regulating proteins. Expressed ubiquitously with highest expression in prostate, ovary and skeletal muscle, DOCK 4 functions as a guanine nucleotide exchange factor (GEF) that activates the small GTPase Rap 1 and, via this activation, plays a role in the regulation of adherens junctions between cells. Similar to other DOCK family members, DOCK 4 contains an N-terminal SH3 domain, a C-terminal proline-rich region and two internal DOCK homology regions designated DHR1 and DHR2. Defects in the gene encoding DOCK 4 result in the inactivation of Rap 1 and are, thus, implicated in the pathogenesis of various cancers such as ovarian, prostate, glioma and colorectal carcinomas. Four isoforms of DOCK 4 are expressed due to alternative splicing events.