Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US, Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxesShips via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal health products, bulky and/or heavy items
DOCK 4 Antibody (R6Y) is a high quality monoclonal DOCK 4 antibody (also designated DOCK 4 antibody) suitable for the detection of the DOCK 4 protein of mouse, rat and human origin. DOCK 4 Antibody (R6Y) is available as the non-conjugated anti-DOCK 4 antibody. DOCK 4 (Dedicator of cytokinesis protein 4) is a cytoplasmic peripheral membrane protein that belongs to the DOCK family of cytokinesis-regulating proteins. Expressed ubiquitously with highest expression in prostate, ovary and skeletal muscle, DOCK 4 functions as a guanine nucleotide exchange factor (GEF) that activates the small GTPase Rap 1 and, via this activation, plays a role in the regulation of adherens junctions between cells. Similar to other DOCK family members, DOCK 4 contains an N-terminal SH3 domain, a C-terminal proline-rich region and two internal DOCK homology regions designated DHR1 and DHR2. Defects in the gene encoding DOCK 4 result in the inactivation of Rap 1 and are, thus, implicated in the pathogenesis of various cancers such as ovarian, prostate, glioma and colorectal carcinomas. Four isoforms of DOCK 4 are expressed due to alternative splicing events.
种属 | 基因名称 | 基因ID | 染色质位置 | 亚型(mRNA)即位号码 | 蛋白质即位号码 | OMIM™ 号码 |
---|---|---|---|---|---|---|
Human | DOCK4 | 9732 | 7q31.1 | XM_006716188, XM_006716189, XM_017012819, XM_017012820, XM_017012821, XM_017012822, XM_017012823, XM_017012824, XM_017012825, NM_014705 | Q8N1I0 | 607679 |
Mouse | Dock4 | 238130 | 12 B1 | XM_006515085, XM_006515086, XM_006515087, XM_006515088, XM_006515089, XM_006515090, XM_017315054, NM_172803 | P59764 | N/A |