Dimebolin dihydrochloride CAS: 97657-92-6
Dimebolin dihydrochloride is a histamine, AR, and Ca channel inhibitor.

Dimebolin dihydrochloride (CAS 97657-92-6)

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Application: Dimebolin dihydrochloride is a histamine, AR, and Ca channel inhibitor
CAS Number: 97657-92-6
Molecular Weight: 392.4
Molecular Formula: C21H25N32HCl
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Dimebolin dihydrochloride, dimebolin (hydrochloride), also known as Dimebon ™, is an orally-available drug, approved in Russia for use as a non-selective antihistamine, that has shown promise in the treatment of neurodegenerative diseases, including Alzheimer′s disease and Huntington′s disease. In addition to preventing the onset and progression of disease by being neuroprotective, Dimebolin appears to promote clinical improvement by increasing cognitive function. At the cellular level, Dimebolin appears to have diverse effects, inhibiting the neurotoxic action of β-amyloid and acting as a calcium channel protein inhibitor, inhibiting NMDA-type glutamate receptors, and preventing mitochondrial leakage. The hydrochloride form of Dimebolin is soluble in both aqueous and organic solvents.


参考文献

1 Lermontova, N.N., Lukoyanov, N.V., Serkova, T.P., et al. Dimebon improves learning in animals with experimental Alzheimer′s disease. Bulletin of Experimental Biology and Medicine 129(6) 640-642 (2000). 2 Doody, R.S., Gavrilova, S.I., Sano, M., et al.

Physical State :
Solid
Solubility :
Soluble in ethanol (~3 mg/ml), DMSO (~10 mg/ml), DMF (~1 mg/ml), PBS, pH 7.2 (~10 mg/ml), and water (>25 mg/ml).
Storage :
Store at -20° C
Refractive Index :
n20D 1.63
IC50 :
Histamine H1 receptor: IC50 = 0.16 µM (human); 5-HT6 receptor: IC50 = 0.89 µM (human); Butyrylcholinesterase: IC50 = 7.9 µM (human); Acetylcholinesterase: IC50 = 45 µM (human); L-type calcium channel: IC50 = 57 µM
Ki Data :
5-HT7 receptor: Ki= 8 nM (human); 5-HT6 receptor: Ki= 26 nM (human); 5-HT2c receptor: Ki= 76 nM (human); 5-HT1a receptor: Ki>100 nM (human)
仅供科研使用。不可用于诊断或治疗。
RTECS :
UV0625000
PubChem CID :
Merck Index :
14: 10391
MDL Number :
MFCD01617545
SMILES :
CC1=CC2=C(C=C1)N(C3=C2CN(CC3)C)CCC4=CN=C(C=C4)C.Cl.Cl

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Certificate of Analysis

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